منابع مشابه
Balanced discussion of second-generation antihistamines’ data
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متن کاملUse of second generation H1 antihistamines in special situations.
Antihistamine drugs are one of the therapeutic classes most used at world level, at all ages and in multiple situations. Although in general they have a good safety profile, only the more recent drugs (second generation antihistamines) have been studied specifically with regard to the more important safety aspects. Given the variety of antihistamine drugs, they cannot all be considered equivale...
متن کاملEffects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport
BACKGROUND The first generation antihistamines, such as diphenhydramine, are fairly potent muscarinic antagonists in addition to being H1 selective antihistamines. The antimuscarinic action is often not desirable since it is in part responsible for the drying of secretions in the airways and the sedative effect. We therefore examined a number of antihistamines for antimuscarinic effects on ion ...
متن کاملThe concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines.
Second generation H1 antihistamines are considered first-line therapy for allergic rhinitis and chronic idiopathic urticaria, largely because of their nonsedating effects. Evaluating pharmacokinetic and pharmacodynamic parameters and clinical efficacy of a drug is important, but models to predict clinical efficacy are lacking. Receptor occupancy (RO), a predictor for human pharmacodynamics and ...
متن کاملSedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis.
BACKGROUND Antihistamines are among the most frequently used medications in the United States. Despite dramatically higher cost, second-generation antihistamines are replacing diphenhydramine because of the perception that they are not constrained by its sedating effects. OBJECTIVE We sought to examine, through meta-analytic procedures, the collective evidence regarding the sedating and perfo...
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ژورنال
عنوان ژورنال: Indian Journal of Drugs in Dermatology
سال: 2016
ISSN: 2455-3972
DOI: 10.4103/2455-3972.184094